Cytoplasmic retention site
WebMar 1, 2013 · Huntington disease is a dominantly inherited neurodegenerative condition caused by polyglutamine expansion in the N terminus of the huntingtin protein (Htt). The first 17 amino acids (N17) of Htt play a key role in regulating its toxicity and aggregation. Both nuclear export and cytoplasm retention functions have been ascribed to N17. WebJun 20, 2000 · Retention by STAT2 may serve to regulate the activity of free p48 and/or guarantee that cytoplasmic pools of preassociated STAT2:p48 are available for rapid activation of the IFN response. These findings suggest that analogous mechanisms may exist for regulating the distribution of other IRF proteins.
Cytoplasmic retention site
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WebMar 21, 2024 · Cytoplasmic protein was extracted and subjected to western blotting analysis using indicated antibodies. (C) HEK293 cells transfected with a Flag-USP11 or … Mitotic entry is determined by a threshold level of active cyclin-B1/CDK1 complex, also known as cyclin-B1/Cdc2 or the maturation promoting factor (MPF). Active cyclin-B1/CDK1 triggers irreversible actions in early mitosis, including centrosome separation, nuclear envelope breakdown, and spindle assembly. In vertebrates, there are five cyclin B isoforms (B1, B2, B3, B4, and …
WebAug 1, 1999 · The MA domain of these viruses contains a "cytoplasmic targeting and retention signal (CTRS)" which is necessary for the intracytoplasmic assembly of virus … WebSep 9, 2024 · Retention of S in the ER reduces its capacity to form syncytia while increased leakage to the plasma membrane increases it. Scale bars: 200 µm. c Quantification of cell-cell fusion as percentage...
WebNov 4, 2013 · Intron retention and cytoplasmic splicing are emerging forms of transcriptional regulation that add to the molecular diversity of mammalian cells. Evidence of the importance of nonnuclear transcript … WebMar 1, 2013 · A cytoplasm retention signal would, in theory, not be affected by these interventions, whereas we observed nuclear accumulation of Htt in the setting of inhibition of nuclear export. Given its high degree of evolutionary conservation, beyond the four amino acid NES motif, it is highly plausible that N17 contains overlapping, but distinct ...
WebJun 1, 2024 · Nucleo‐cytoplasmic shuttling of transcription factors is used by the cell to control gene expression programs in response to the environment. Transcription …
WebMar 21, 2024 · Cytoplasmic p21 is responsible for paclitaxel resistance in ovarian cancer A2780 cells. European journal of gynaecological oncology. 2015;36:662-6 19. Xia X, Ma … the prop roomWebThe nuclear envelope reappears around the chromosomes, endoplasmic reticulum is rebuilt and cytoplasmic microtubules reassemble. The transcription and biosynthetic functions … signdesign and manufacturingWebMar 15, 2024 · STX exposure promotes YAP1 cytoplasmic retention (A-B) Immunofluorescence analysis performed in N2a cells treated with STX. Scale bar, 10 … the props awardsWeb43 minutes ago · How Aflac is winning at employee retention and getting workers back to the office: on-site doctors, therapists, and childcare. BY Amber Burton and Paolo … the propsWebNational Center for Biotechnology Information sign designs now kingwood txWeb... data above demonstrated that the loss of Hippo signaling in the liver resulted in the cytoplasmic retention of both Skp2 and FoxO through the activation of Akt, which promotes Skp2-mediated... sign delivery memphis tnWeb43 minutes ago · How Aflac is winning at employee retention and getting workers back to the office: on-site doctors, therapists, and childcare. BY Amber Burton and Paolo Confino. April 14, 2024, 11:45 AM UTC. sign declaration of independence