Drug sensitivity in cancer gdsc database
WebNov 22, 2012 · The Genomics of Drug Sensitivity in Cancer (GDSC) provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies. Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are … WebApr 10, 2024 · I) The half maximal inhibitory concentration (IC50) of ATRA in OTUD6B-knockdown and control KYSE30 or KYSE450 cells were analyzed in the genomics of drug sensitivity in cancer (GDSC) database using RNA-sequencing data. n = 3, mean ± SD, unpaired t-test, * p < 0.05, *** p < 0.001.
Drug sensitivity in cancer gdsc database
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WebMar 29, 2024 · In this study we first analyzed GDSC (Genomics of Drug Sensitivity in Cancer) and DepMap database and disclosed that hematologic malignancies (HMs) were relatively sensitive to CHK1i or CHK1 ... WebApr 13, 2024 · HIGHLIGHTS. who: Weijun Pan from the Jinan University, China have published the research work: The molecular subtypes of triple negative breast cancer were defined and a ligand-receptor pair score model was constructed by comprehensive analysis of ligand-receptor pairs, in the Journal: (JOURNAL) what: In this study, 29 pairs of LR …
WebDec 13, 2024 · Possible OC medications were forecasted utilizing the Genomics of Drug Sensitivity in Cancer (GDSC) database and connectivity map (CMap). TIMErisk was developed based on ALPK2, CPA3, PTGER3, CTHRC1, PLA2G2D, CXCL11, and ZNF683. High TIMErisk was recognized as a poor factor for survival in the GEO and TCGA … WebDrug sensitivity was at the core of individualized cancer chemotherapy in the past. Before the advent of drug sensitivity testing, cancer clinicians made therapeutic decisions on …
WebThe Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. ... drug sensitivity data are integrated with large genomic datasets obtained from the Catalogue of Somatic Mutations in Cancer database ... WebGenomics of drug sensitivity in cancer analysis. ... The Spearman correlation between the MMM score and drugs’ IC50 based on the GDSC database in PCa cell lines. Cell culture, transfection and transwell assays. 22RV1 was used for transwell assays. The details of cell culture, transfection and transwell assays could be found in supplemental ...
WebGenomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Yang et al., (2013) Nucl. Acids Res. 41 (Database issue): D955 … Compounds - Home page - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Features - Home page - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Cell Lines - Home page - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Our drug sensitivity data and genetic correlations are freely available through … The Genomics of Drug Sensitivity of Cancer (GDSC) database now contains data for … Downloads - Home page - Cancerrxgene - Genomics of Drug Sensitivity in Cancer STR profiles of cell lines Cell line authentication. Concerns around the … A cancer-specific analysis correlates drug sensitivity for cancer cell lines of the … Cookies Policy - Home page - Cancerrxgene - Genomics of Drug … Register - Home page - Cancerrxgene - Genomics of Drug Sensitivity in Cancer
WebFeb 1, 2015 · The GDSC project includes experiments describing the response to almost 200 anticancer therapeutics in more than 1000 cancer cell lines. The cell line drug sensitivity data were integrated with large genomic datasets in the COSMIC database to identify molecular markers of cancer drug response. In the GDSC website, drug … christchurch landscapingWebApr 14, 2024 · The majority of lung cancer patients are diagnosed with metastatic disease. This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors … christchurch law internshipsWebApr 28, 2024 · The databases of Cancer Cell Line Encyclopedia (CCLE) and Genomics of Drug Sensitivity in Cancer (GDSC) projects contain gene expression levels from next … christchurch lat longWebApr 12, 2024 · The potential applicability of the RMS model in predicting the therapeutic responsiveness was assessed through the Genomics of Drug Sensitivity in Cancer … geophysicist salary houstonWebJan 19, 2024 · In this study, we developed a network-based method for predicting the drug sensitivity of pan-cancer cell lines in the GDSC database. Several studies have proposed network-based methods for drug response prediction on single omics data [ 20 , 21 ], whereas the current study used multi-modal genomic and cheminformatic data. geophysicist salary 2020WebMar 22, 2024 · In addition, gene set enrichment analysis (GSEA) was used to explore the potential functional mechanisms of P4HA3 in pan-cancer. Finally, P4HA3-related drugs were searched in CellMiner, Genomics of Drug Sensitivity in Cancer (GDSC), and Cancer Therapeutics Response Portal (CTRP) databases. christchurch latchingdonWebJul 14, 2016 · NEW YORK (GenomeWeb) – The developers of the Genomics of Drug Sensitivity in Cancer database have updated the resource to include several large … christchurch law firms