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Irisin ferroptosis

WebOct 28, 2024 · Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. WebDec 1, 2024 · Zhang et al. found that irisin reduced ROS level, iron content, MDA level, increased GSH level in mice, and adjusted the expression of GPX4 and ACSL4 to reduce ferroptosis. In the process of the study, irisin also inhibited ROS accumulation and iron content increase in HK-2 cells. And improve the function of mitochondria [51].

Targeting Ferroptosis: Pathological Mechanism and Treatment of …

WebJun 1, 2024 · Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis … WebRecently, irisin treatment prevented I/R lung damage by suppressing ferroptosis through the Nrf2/HO-1 axis , which was similar to the effect of Fer-1. These findings indicate the … service des loisirs bon pasteur https://dovetechsolutions.com

Ferroptosis in liver disease: new insights into disease mechanisms …

WebJan 15, 2024 · Irisin serves as a novel approach to eliciting cardioprotection, which is associated with the improvement of mitochondrial function and significantly attenuated hypoxia/reoxygenation (H/R), as indicated by the reduction of lactate dehydrogenase (LDH) leakage and apoptotic cardiomyocytes. 99 PDF View 1 excerpt, references background WebOct 28, 2024 · Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases. WebJul 1, 2024 · Ferroptosis contributes to the onset or progression of various metabolic diseases. Ferritinophagy is a selective type of autophagy, which induces ferroptosis by degrading ferritin and inducing iron overload. Ferritinophagy inhibition may ameliorate ferroptosis and ease the management of metabolic diseases. Ferroptosis, which triggers … pal\u0027s qj

Research progress of traditional Chinese medicine in ferroptosis ...

Category:Irisin Is a Positive Regulator for Ferroptosis in Pancreatic …

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Irisin ferroptosis

Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusio…

WebIrisin consists of 112 aa residues. Irisin is a cleavage protein of fibronectin type III domain 5 (FNDC5). Mouse, rat, and human irisin are 100% identical; the rates of similarity are 85% … WebMay 12, 2024 · Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways).

Irisin ferroptosis

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WebSep 9, 2024 · Irisin, a proteolytic cleavage product of fibronectin type III domain-containing protein 5 (FNDC5), is a recently characterized multi-functional myokine with hormonal … WebSep 1, 2024 · The effect of irisin on ferroptosis was confirmed in LPS-treated hepatocytes and CLP-induced septic mice. Inhibition of glutathione peroxidase 4 (GPX4), a central …

WebOct 5, 2024 · Ferroptosis was first identified in 2012 as a novel form of regulated cell death (RCD). It is characterized by excessive accumulation of intracellular lipid reactive oxygen species (ROS) and... WebSep 1, 2024 · Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis in the pathogenesis of SAE and demonstrate that irisin attenuated cognitive dysfunction in SAE mice via inhibition of hippocampus ferroptosis.

WebMay 7, 2024 · Ferroptosis is a form of cell death that is regulated by multiple genes and involves multiple metabolic processes, such as iron homeostasis, amino acid metabolism and lipid peroxidation. The mechanism is very complex as is shown in Figure 1, and it will be better explained in the following aspects. FIGURE 1 Figure 1. Main mechanisms of … WebIrisin, a proteolytic cleavage product of fibronectin type III domain- containingprotein5(FNDC5),isarecentlycharacterizedmulti-func- tional myokine with …

WebDec 8, 2024 · The upregulation of GPX4 leads to an irisin-mediated decrease in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R). However, the protective effect of irisin …

WebMay 25, 2024 · Ferroptosis is an iron-dependent, nonapoptotic cell death method characterized by abnormal accumulation of lipid hydroperoxide and related lipophilic reactive oxygen species (ROS) in the cell membrane [ 7, … pal\\u0027s qkWebSep 17, 2024 · Intriguingly, Yang et al. found that irisin was a positive regulator of ferroptosis. Irisin decreased GXP4 expression and upregulated ROS production to … pal\\u0027s qlWebDec 8, 2024 · The upregulation of GPX4 leads to an irisin-mediated decrease in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R). However, the protective effect of irisin was disrupted by GPX4 inhibitor RSL3 (Zhang J. et al., 2024). Ferroptosis is closely related to hypertensive brain injury. pal\u0027s qhWebAug 5, 2024 · Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer Regulated cell death by way of ferroptosis involves iron-dependent accumulation of cellular reactive … pal\u0027s qiWebMar 17, 2024 · Irisin Mitigates Ferroptosis and Mitochondria Dysfunction in LPS-Induced HK2 Cells. Based on the aforementioned findings in vivo, we next evaluated the function … pal\u0027s qkservice des migrants fribourgWebFerroptosis is an iron-dependent programmed cell death (PCD), which is distinct from other types of cell death such as apoptosis, necrosis, pyrosis, and autophagy ( Dixon et al., 2012 … pal\\u0027s qm