http://exposome-explorer.iarc.fr/compounds/2284 Web21 feb. 2024 · Metabolism and effect of 7-oxo-lithocholic acid 3-sulfate on bile flow and biliary lipid secretion in rats. Yamashita H, Setchell KD. Hepatology, 20(3):663-671, 01 …
Bile Acid Sulfation: A Pathway of Bile Acid Elimination and ...
Web1 feb. 2008 · In conclusion, lithocholic acid was extensively metabolized by multiple P450 enzymes with the predominant biotransformation pathway being hydroxylation at the 6β-position. Lithocholic acid is a lipid-soluble hepatotoxic bile acid that accumulates in the liver during cholestasis. A potential detoxification pathway for lithocholic acid involves … WebThe starting cholic acid was protected as the tetrahydropyran ether (THP) derivative, reduced to the C-24 alcohol and oxidized to the protected aldehyde. This aldehyde was then coupled with methyl 3-hydroxypropionate using 2 equiv. of lithium diethylamide at −65 °C to produce methyl (24RS,25RS)-24,27-dihydroxy-3α,7α,12α,tris[(tetrahydropyran-2-yl)oxy] … campground layout
The metabolism of lithocholic acid and lithocholic acid-3-alpha …
Web9 apr. 2024 · Pregnanolone sulfate acts only as a negative allosteric modulator (Malayev et al., 2002; Chvojkova et al., ... to 3 μM lithocholic acid was examined. The results of this study showed, that the potentiation effect of lithocholic acid is significantly reduced in F48A and V43A mutants and completely inhibited in the Y42A mutant. Web甘氨熊脱氧胆酸3-硫酸钠盐 Glycoursodeoxycholic Acid-3-Sulfate Sodium Salt 牛磺熊去氧胆酸3-硫酸钠盐 Tauroursodeoxycholic Acid-3-Sulfate Sodium Salt 石胆酸-3-硫酸钠盐 Lithocholic Acid-3-Sulfate Sodium Salt 64936-81-8 WebIsolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid … first time home buyer framework