Phospholipase a2 receptor antibody panel
WebMar 29, 2024 · Also known as. PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R. Summary. This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. WebThe relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy The …
Phospholipase a2 receptor antibody panel
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WebFeb 20, 2024 · M-type phospholipase A2 receptor 1 (PLA2R) has been described as a major antigen in iMN, with anti-PLA2R antibodies (Abs) present in ∼70% of incident patients [ 2, 3 ]. The specificity of anti-PLA2R Abs for the diagnosis of iMN, albeit not absolute, is now well established [ 3–5 ]. WebAug 1, 2002 · The phospholipase A 2 receptor (PLA 2 R) is a type I transmembrane glycoprotein related to the C-type animal lectin family that includes the mannose receptor.PLA 2 R regulates a variety of biological responses elicited by specific types of secretory PLA 2 s (sPLA 2 s). Group IB sPLA 2 (sPLA 2-IB) acts as an endogenous PLA 2 …
WebOct 31, 2024 · Recently, great progress has been made in understanding the pathogenesis of membranous nephropathy (MN) with the discovery of autoantibodies (Abs) to M-type phospholipase A2 receptor (PLA2R) in serum and in immunocomplexes deposited in glomerulus in most adult patients with primary MN. Objective WebAnti-PLA2R antibody podocyte apoptosis protein binding actin Introduction The pathogenesis of membranous nephropathy (MN) involves in situ formation of subepithelial immune deposits that induce glomerular injury by damaging podocytes through complement-dependent processes [ 1 ].
WebAnti-phospholipase A2 receptor autoantibody (PLA2R-Ab) plays a critical role in the pathogenesis of primary membranous nephropathy (PMN), an autoimmune kidney disease characterized by immune deposits in the glomerular subepithelial spaces and proteinuria. However, the mechanism of how PLA2R-Abs interact with the conformational epitope(s) … WebFeb 1, 2024 · Patients testing positive for phospholipase A2 receptor (PLA2R) antibodies. CA, cancer; CXR, chest x-ray; eGFR, estimated glomerular filtration rate; ELISA, enzyme-linked immunosorbent assay; IFA, immunofluorescence assay; NSAIDs, nonsteroidal antiinflammatory drugs; PSA, prostate-specific antigen.
WebMar 30, 2024 · The autoimmune nature of adult MN was first discovered upon the identification of antibodies to the phospholipase A2 receptor (PLA2R), located within …
WebPhospholipase A2 Receptor (PLA2R) Antibody, ELISA - Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing … high rich supermarketWebPhospholipase A2 Receptor (PLA2R) Antibody Panel Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing … high rich shoppeWebMar 24, 2015 · To assess the relationships among treatment effect, circulating nephritogenic anti-phospholipase A2receptor (anti-PLA2R) autoantibodies and genetic … how many calories in a reese\u0027sWebOct 3, 2024 · In 2009, antibodies to the M-type receptor of phospholipase A2 (anti-PLA2R) were identified in idiopathic MN patients, both within the kidney and in the circulation. The clinical course of idiopathic MN is variable and ranges from spontaneous remission to end-stage renal disease. how many calories in a red bird peppermintWebTest Usage. Primary membranous nephropathy is an autoimmune disease which demonstrates autoantibodies to the M-type phospholipase A2 receptor (PLA2R) in up to … high rich proteinWebMar 29, 2012 · Lane 1: Wild-type HAP1 whole cell lysate (20 µg) Lane 2: Cytosolic Phospholipase A2 knockout HAP1 whole cell lysate (20 µg) Lane 3: HeLa whole cell lysate … how many calories in a raspberry donutWebSep 9, 2024 · Background Membranous nephropathy (MN) is an autoimmune disease induced by circulating antibodies against the podocyte protein phospholipase A2 receptor 1 (PLA2R1-ab) in 80% of patients and represents the leading cause of nephrotic syndrome in adults. PLA2R1-ab levels correlate with disease activity and treatment response. However, … high rich potassium foods