WebOct 6, 2024 · DNA polymerase theta (Polθ) is a specialized DNA polymerase that can join two DNA ends with single-stranded overhangs. Polθ uses very short complementary DNA sequences present in the single ... WebMar 31, 2016 · DNA polymerase kappa (polκ) is the only known Y-family polymerase that bypasses BP-dG accurately and thus protects cells from genotoxic BP. Here, we report the structures of human polκ in complex with DNA containing either a normal guanine (G) base or a BP-dG adduct at the active site and a correct deoxycytidine.
Structure and mechanism of error-free replication past the major …
WebJun 6, 2024 · Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.We previously reported on the development and characterization of indole barbituric acid … WebMar 29, 2024 · Results show that the DNA polymerase kappa N-clasp is a key structural feature that accounts for the dA adduct blockage and the near-error-free bypass of the … ccvt\u0027s
Error-prone bypass of certain DNA lesions by the human DNA polymerase κ
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