網頁2024年2月2日 · Neuroendocrine prostate cancer (NEPC) is a lethal form of prostate cancer characterized by loss of AR expression and thus resist ADT. In the AR-negative PC3 cells, SMAD3 was reported to promote HIF-1α chromatin binding under hypoxia to promote neuroendocrine (NE) phenotype ( 15 ). 網頁2024年5月16日 · We identified broad expression of STEAP1 (87% positive) in lethal metastatic prostate cancer, even more so than prostate-specific membrane antigen (PSMA, 60% positive) which is a...
Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate …
網頁"Metastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung… Publication Writer, … 網頁2024年8月15日 · Abstract. AMG509, a novel STEAP1 x CD3 T cell-recruiting XmAb® 2+1 bispecific immune therapy for the treatment of prostate cancer and Ewing sarcoma. … gas fireplace logs katy texas
Targeting advanced prostate cancer with STEAP1 chimeric …
網頁2024年8月20日 · Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, … 網頁STEAP1 is one of six-transmembrane epithelial antigen of prostate (STEAP) highly expressed in human prostate cancer and is up-regulated in multiple cancers, including bladder, colon, breast, Ewing and lung cancers. Immunohistochemical analysis 網頁2024年11月17日 · The Six Transmembrane Epithelial Antigen of the Prostate 1 ( STEAP1) gene was identified as overexpressed in PCa compared to non-malignant tissues [ 8 ]. The STEAP1 protein is mainly located in the plasma membrane of epithelial cells, particularly at cell–cell junctions where it may act as an ion channel or transporter protein [ 8 ]. gas fireplace logs murfreesboro tn